I think it’s totally possible to “follow my bliss” and be fulfilled.
But first, I have to demonstrate the brutal/ruthless honesty required to know myself—to know what my “bliss” even is—by tracking the evidence/tendencies that reveal not just my shining glories, but also my darkest failings. Then I have to demonstrate the discipline, creativity, and urgency to crush/circumvent/stifle the [inconveniences, bureaucracy/opposition/etc.] that keep me from hitting my target.
If I do all that, then “following my bliss” is a piece of cake.